The 26.04 Data Release includes data from the following studies:

Human data

The SuperAgers Family Study enrolls individuals 95+, their children, and spouses to build a genotype-phenotype database of exceptionally long-lived individuals. Using salivary DNA for whole exome sequencing, the study aims to identify protective genetic variants, uncover mechanisms of healthy aging, and support the development of interventions targeting age-related diseases.

This release includes individual-level demographic metadata and clinical data for 767 participants from the SuperAgers Family Study.

Human Serum Determinants of Aging

This study features an investigation of human longevity using metabolomics and proteomics, data collected through a case-cohort design. Longevity cases were defined as individuals who lived longer than 98% of their peers, based on U.S. life expectancy data. Participants came from four long-term studies of older adults—MrOS, SOF, Health ABC, and CHS. A random sample of participants was selected for comparison, including some who also reached exceptional ages. Data from the CHS study are hosted on dbGaP. Data from the MrOS, SOF, and Health ABC cohorts are hosted on the ELITE Portal.

This release includes additional proteomics data from the New England Centenarian Study (NECS) cohort and revised study and methods descriptions.