Welcome to the Exceptional Longevity Translational Resources (ELITE) Portal! The ELITE Portal (eliteportal.synapse.org) is a new research hub for disseminating data and other resources from translational longevity research projects.
How do I use the ELITE Portal?
Join us for our upcoming ELITE Portal Technical Workshop to learn how to navigate the portal, explore metadata, and download data.
Our Help Docs also have articles and walkthrough User Guides for Getting Started, Exploring Data, Analyzing Data, and Data Governance.
What data is available?
Multi-omic Signatures of Longevity Across Avian and Mammalian Species
This study investigates the molecular mechanisms of longevity in birds by analyzing transcriptomic, proteomic, and metabolomic data across multiple tissues to identify key gene expression biomarkers linked to lifespan. By comparing these longevity signatures to those previously identified in mammals, the research aims to uncover both universal and species-specific pathways that regulate lifespan across vertebrates, potentially informing future lifespan-extending interventions.
Mouse M005 Study – Metabolomics
This study investigates the effects of five longevity-enhancing interventions on 12-month-old UM-HET3 mice compared to untreated controls and young (4-month-old) mice. The primary objective is to identify metabolomic differences across six organs to understand how these interventions influence metabolic pathways associated with aging and extended longevity.
The Phenome-wide Association Study of Aging: Data Files and a Web Resource
This Aging-PheWAS viewer enables users to search their gene of interest for genetically predicted tissue-specific gene expression associations with a collection of aging-related traits and outcomes. Full results are available for download.
The Mendelian Randomization of Human Longevity Using Genetically-Predicted Exposures from the GWAS Catalog Study
This MRGWAS viewer allows exploration of results of a two Sample Mendelian Randomization used to analyze the relationship between significantly associated GWAS traits and five distinct definitions of longevity. Full results are available for download.
The Long Life Family Study
The Long Life Family Study (LLFS) is a large, international, longitudinal study focused on the genetics and familial traits of exceptional longevity, involving over 4,900 extensively phenotyped individuals from families selected for clustering of extreme survival. Using standardized protocols across multiple centers, the study has generated rich multi-omic and phenotypic data to uncover factors contributing to healthy aging.
The Characterization of Gene Associations with Aging-Related Traits with a Genetically-Predicted Transcriptome-Wide Association Study
The Characterization of gene associations with aging-related traits with a genetically-predicted transcriptome-wide association study (ADAMTS7) provides analyses of candidate genes and the association of Longevity-Associated Variants (LAVs) with aging-related traits and diseases.
The Single Cell Transcriptomic Analysis of PBMCs in Extreme Longevity Study
This study provides data from 7 centenarian samples (over 100 years of age) and 2 younger control samples (20-59 years of age).
The AD Cerebral Organoid Single-Cell Transcriptome Study
This study investigated the cell type-specific mechanisms involved in Alzheimer’s disease (AD) through the development of 3D cerebral organoid-based models of the disease exploiting well-established isogenic hiPSC carrying heterozygous familial AD mutations (PSEN1M146V and APPswe).
What data is coming in the future?
Get Notified About New Data
Our resources are still growing! Subscribe to our newsletter to be notified when new data, tools, or resources are released to the portal.
Data releases happen at the end of every month when data is available. Check on the Explore – Studies page to see what data is coming soon – these studies will be labeled with Data Status = Data Pending. We are also working on illustrating our expected data pipeline in more detail – stay tuned!
More Questions?
Still have questions? Reach out to us in the ELITE Portal Discussion Forum.