The 25.2 Data Release includes data from the following studies:
Human data
The Long Life Family Study (LLFS), RNA Sequencing data
The Long Life Family Study (LLFS) is an international collaborative effort investigating the genetics and familial components of exceptional survival, longevity, and healthy aging. Families were recruited based on clustering of exceptional survival, identified through elderly probands (typically in their 90s) reporting their parents’ and siblings’ survival history. This collection of 539 families, encompassing 4,953 individuals, is a valuable resource for studying human longevity and healthy aging. Comprehensive in-home visits provided extensive phenotyping across major domains of aging, including cognitive, physical, and biochemical measures. The study will generate GWAS chip data and multiple omic analyses (whole genome sequencing, methylome, transcriptome, metabolome, and proteome).
- This release provides raw RNA Sequencing data.
Non Human data
This study aims to uncover the molecular mechanisms underlying longevity in birds and compare them to those previously identified in mammals. The researchers identified tissue-specific and cross-tissue gene expression biomarkers associated with lifespan by analyzing multiple bird species’ transcriptomic, proteomic, and metabolomic data. Using RNA-seq data and advanced statistical models, they constructed longevity signatures across four organs—liver, kidney, brain, and heart. Comparative analyses with mammalian data will highlight conserved and unique lifespan-regulating pathways across vertebrates. This multi-omic approach will provide insights into universal longevity strategies and potential targets for lifespan-extending interventions.