The 24.12 Data Release includes data from the following studies:
Human data
The Long Life Family Study (LLFS), Whole Genome Sequencing data
The Long Life Family Study (LLFS) is an international collaborative effort investigating the genetics and familial components of exceptional survival, longevity, and healthy aging. Families were recruited based on clustering of exceptional survival, identified through elderly probands (typically in their 90s) reporting their parents’ and siblings’ survival history. This collection of 539 families, encompassing 4,953 individuals, is a valuable resource for studying human longevity and healthy aging. Comprehensive in-home visits provided extensive phenotyping across major domains of aging, including cognitive, physical, and biochemical measures. The study will generate GWAS chip data and multiple omic analyses (whole genome sequencing, methylome, transcriptome, metabolome, and proteome).
- This release provides Whole Genome Sequencing data.
Non Human data
The Longevity Consortium (LC), Mouse M005 study
The Mouse M005 study investigates five longevity-enhancing interventions’ metabolic and physiological impacts on UM-HET3 mice, a genetically heterogeneous model frequently used in aging research. The interventions include caloric restriction (CR), rapamycin, canagliflozin, 17α-estradiol (17α-E2), and acarbose, all of which are associated with extended lifespan. By comparing 12-month-old treated mice with untreated age-matched controls and young (4-month-old) mice, the study aims to identify metabolomic changes across six tissues: blood, liver, kidney, inguinal fat, gonadal fat, and gastrocnemius muscle.
- This release provides metabolomics data.