The 24.2 Data Release includes data from the following studies:
Human data
The AD cerebral organoid single-cell transcriptome study
This study reflects supplementary research to the research pursued through the NIA-funded Longevity Genomics project (grant number U24AG051129). The study investigated the cell type-specific mechanisms involved in Alzheimer’s disease (AD) through the development of 3D cerebral organoid-based models of the disease exploiting well-established isogenic hiPSC carrying heterozygous familial AD mutations (PSEN1M146V and APPswe).